DAS dépression affective saisonnière (SAD seasonal affective disorder),

dépression hivernale (winter blues, winter depression)

¤ Spécification du caractère saisonnier

Spécifier si :

avec caractère saisonnier (peut s'appliquer aux modalités évolutives des Episodes dépressifs majeurs, des Troubles bipolaires I et II ou du Trouble dépressif majeur récurrent).

A. Il existe une relation temporelle régulière entre la survenue des Episodes dépressifs majeurs du Trouble bipolaire I ou bipolaire II ou du Trouble dépressif majeur récurrent et une période particulière de l'année (p. ex. début régulier des Episodes dépressifs majeurs majeurs à l'automne ou en hiver).

NB. Ne pas inclure les cas où il y a une relation évidente entre la saison et un stress psychosocial (p. ex.chômage régulier chaque hiver).

B. Les rémissions complètes (ou la transformation en une manie ou une hypomanie) surviennent aussi au cours d'une période particulière de l'année (p. ex. disparition de la dépression au printemps).

C. Présence d'au moins deux Episodes dépressifs majeurs au cours des deux dernières années, confirmant la présence d'une relation temporelle saisonnière selon la définition des critères A et B. Aucun Episode dépressif majeur de caractère non saisonnier n'est survenu au cours de cette épisode.

D. Au cours de la vie entière du sujet, les Episodes dépressifs majeurs (décrits ci-dessus) sont nettement plus nombreux que les Episodes dépressifs majeurs non saisonniers.

 

DSM-IV criteria for seasonal pattern specifier
Specify if :

with seasonal pattern (can be applied to the pattern of major depressive episodes in bipolar I disorder, bipolar II disorder, or major depressive disorder, recurrent):
A. There has been a regular temporal relationship between the onset of major depressive episodes in bipolar I or bipolar II disorder or major depressive disorder, recurrent, and a particular time of year (e.g. regular appearance of the major depressive episode in autumn or winter)
B. Full remissions (or a change from depression to mania or hypomania) also occur at a
characteristic time of year (e.g. depression disappears in the spring).
C. In the last 2 years, two major depressive episodes have occurred that demonstrate the temporal season relationship defined in criteria a and b, and no non-seasonal major depressive episode has occurred during the same period.
D. Seasonal major depressive episodes (as described above) substantially outnumber the non-seasonal major depressive episodes that may have occurred over the individual’s lifetime.
Note: Do not include cases in which there is an obvious effect of season-related psychosocial stressors (e.g. regularly being unemployed each winter)

Source: American Psychiatric Association (1994).

 

SAD criteria of Rosenthal et al (1984)

1) A history of major affective disorder, according to Research Diagnostic Criteria (Spitzer et al 1978)

2) At least two consecutive previous years in which the depressions developed during fall or winter and remitted by the following spring or summer

3) Absence of any other Axis I DSM-III psychiatric disorder (American Psychiatric Association 1980)

4) Absence of any clear-cut seasonally changing psychosocial variables that would account for the seasonal variability in mood and behaviour

References

Rosenthal NE, Sack DA, Gillin JC et al. Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy. Archives of General Psychiatry 1984; 41: 72-80.

Spitzer RL, Endicott J, Robins E. Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry 1978; 35: 773-782.

http://www.priory.com/psych/SAD.htm

 

Lemoine P , Dépressions saisonnières. Encycl Méd Chir (Paris, France), Psychiatrie, 37-110-A-11, 1995, 5 P

http://www.normanrosenthal.com/articles_2.html

Articles and Publications

Books:

edit with Blehar M., Seasonal Affective Disorders and Phototherapy, New York: Guilford Press, 1989.
Seasons of the Mind: Why you get the winter blues and what you can do about it. New York: Bantam Books, 1989.
Winter Blues. New York: Guilford Press, 1993; second edition 1998.
co-author with Ore D.A., Reich W.and Wehr T.A., How to Beat Jet Lag, New York: Henry Holt, 1993.
St. John's Wort: The Herbal Way to Feeling Good. New York: Harper Collins, 1998.
The Emotional Revolution: How the New Science of Feeling Can Transform Your Life. Citadel, 2002.

Original Articles:

Rosenthal NE, Rosenthal LN, Stallone F, Fleiss J, Dunner DL, Fieve RR: Psychosis as a predictor of response to lithium maintenance treatment in bipolar affective disorder. Journal of Affective Disorders, 1: 237-245, 1979.

Rosenthal NE, Yudofsky S : ECT in a depressed patient with adult onset diabetes mellitus. American Journal of Psychiatry, 137: 100-101, 1980.

Rosenthal NE, Davenport Y, Cowdry RW, Webster MH, Goodwin FK: Monoamine metabolites in cerebrospinal fluid of depressive subgroups. Psychiatry Research, 2: 113-119, 1980.

Rosenthal NE, Rosenthal LN, Stallone F, Dunner DL, Fieve RR: Toward the validation of RDC schizoaffective disorder. Archives of General Psychiatry, 37: 804-810, 1980.

Rosenthal NE, Lewy AJ, Wehr TA, Goodwin FK, Newsome DA : Manic-depressive patients may be supersensitive to light. Lancet, 383-384, Feb 14, 1981.

Rosenthal NE, Wilson LG, Dunner DL: The phenomenology of bipolar I manic-depressive illness. Canadian Journal of Psychiatry, 27(2): 150-154, 1982.

Rosenthal NE, Lewy AJ, Kern HA, Wehr TA: Bright artificial light treatment of a manic-depressive patient with a seasonal mood cycle. American Journal of Psychiatry, 139: 1496-1498, 1982.

Rosenthal NE, Lewy AJ, Wehr TA, Kern HE, Goodwin FK: Seasonal cycling in a bipolar patient. Psychiatry Research, 8: 25-31, 1983.

Rosenthal NE, Linnoila M, Karoum F, Potter WZ: Electroconvulsive treatment and lithium carbonate: Their effects on norepinephrine metabolism in patients with primary major depressions. Archives of General Psychiatry, 40: 677-680, 1983.

Rosenthal NE, Rosen LN, Dunner DL, Fieve RR: Social outcome compared in psychotic and non-psychotic bipolar patients. Journal of Nervous and Mental Diseases, 171(5): 272-275, 1983.

Rosenthal NE, Rosen LN, Vandusen P, Dunner DL, Fieve RR: Age of onset and psychotic symptomatology in bipolar I and schizoaffective disorder. American Journal of Psychiatry, 140(11): 1523-1524, 1983.

Rosenthal NE, Sack DA, Gillin JC, Lewy AJ, Goodwin FK, Davenport Y, Mueller PS, Newsome DA, Wehr TA: Seasonal affective disorder: A description of the syndrome and preliminary findings with light therapy. Archives of General Psychiatry, 41: 72-80, 1984.

Rosenthal NE, Sack DA, Carpenter CJ, Parry BL, Mendelson WB, Wehr TA: Antidepressant effects of light in seasonal affective disorder. American Journal of Psychiatry, 142: 163-170, 1985.

Rosenthal NE, Wehr TA, Sack DA, Duncan W, Gillin JC, Goodwin FK: Sleep and circadian rhythms in affective patients isolated from external time cues. Psychiatry Research, 5: 327-339, 1985.

Rosenthal NE, Sack DA, Nurnburger J, Ashburn E, Wehr TA: The potentiation of antidepressant medications by phase-advance of the sleep-wake cycle. American Journal of Psychiatry, 142: 606-608, 1985.

Rosenthal NE, Wehr TA, Sack DA, Gillin JC: Antidepressant effects of sleep deprivation in bright and dim light. Acta Psychiatrica Scandinavica, 72: 161-165, 1985.

Rosenthal NE, James SP, Wehr TA, Sack DA, Parry BL, : Treatment of seasonal affective disorder with light in the evening. British Journal of Psychiatry, 147: 424-428, 1985.

Rosenthal NE, Sherer MA, Weingartner H, James SP: Effects of melatonin on performance testing in patients with seasonal affective disorder. Neuroscience Letters, 58: 277-282, 1985.

Rosenthal NE, Carpenter CJ, James SP, Parry BL, Rogers SLB, Wehr TA: Seasonal affective disorder in children and adolescents. American Journal of Psychiatry, 143: 356-358, 1986.

Rosenthal NE, Hellekson CJ, Kline JA : Phototherapy for seasonal affective disorder in Alaska. American Journal of Psychiatry, 143(8): 1035-1037, 1986.

Rosenthal NE, Wehr TA, Sack DA, Jacobsen F, Tamarkin L, Arendt J : Phototherapy of seasonal affective disorder: Time of day and suppression of melatonin are not critical for antidepressant effects. Archives of General Psychiatry, 43: 870-875, 1986.

Rosenthal NE, James SP, Wehr TA, Sack DA, Parry BL, Rogers SLB : The dexamethasone suppression test in seasonal affective disorder. Comprehensive Psychiatry, 27: 224-226, 1986.

Rosenthal NE, Mendelson WB, James SP, Garnett D, Sack DA : A psychophysiological study of insomnia. Psychiatry Research, 19: 267-284, 1986.

Rosenthal NE, Roy-Byrne PP, Rubinow DR, Hoban MC, Parry BL, Nurnberger JI, Byrnes S: Premenstrual changes: A comparison of five populations. Psychiatry Research, 17: 77-85, 1986.

Rosenthal NE, Jacobsen FM, Wehr TA, Sack DA, James SP, Parry BL : Seasonal Affective Disorder: A review of the syndrome and its public health implications. American Journal of Public Health, 77 (1): 57-60, 1987.

Rosenthal NE, Wehr TA, Sack DA : Sleep reduction as a final common pathway in the genesis of mania. American Journal of Psychiatry, 144: 201-204, 1987.

Rosenthal NE, Wehr TA, Skwerer RG, Jacobsen FM, Sack DA : Eye- versus skin-phototherapy of seasonal affective disorder. American Journal of Psychiatry, 144: 753-757, 1987.

Parry BL, Rosenthal NE, James SP, Wehr TA: Treatment of a patient with seasonal premenstrual syndrome. American Journal of Psychiatry, 144: 762-766, 1987.

Jacobsen FM, Wehr TA, Skwerer RG, Sack DA, Rosenthal NE: Morning versus midday phototherapy of seasonal affective disorder. American Journal of Psychiatry, 144: 1301-1305, 1987.

Rosenthal NE, Rotter A, Jacobsen FM, Skwerer RG: No mood-altering effects found following treatment of normal subjects with bright light in the morning. Psychiatry Research, 22: 1-9, 1987.

Jacobsen FM, Sack DA, Wehr TA, Rogers S, Rosenthal NE: Neuroendocrine response to 5-hydroxytryptophan in seasonal affective disorder. Archives of General Psychiatry, 44: 1086-1091, 1987.

Wehr TA, Sack DA, Rosenthal NE: Seasonal affective disorder with summer depression and winter hypomania. American Journal of Psychiatry, 144: 1602-1603, 1987.

James SP, Mendelson WB, Sack DA, Rosenthal NE, Wehr TA: The effect of melatonin on normal sleep. Neuropsychopharmacology, 1: 41-44, 1987.

Rosenthal NE, Jacobsen FM, Sack DA, Arendt J, James SP, Parry BL, Wehr TA: Atenolol in seasonal affective disorder: A test of the melatonin hypothesis. American Journal of Psychiatry, 145: 52-56, 1988.

Rosenthal NE, Wehr TA, Sack DA, Cowdry RW: Rapid cycling affective disorder: Contributing factors and treatment responses in 51 cases. American Journal of Psychiatry, 145: 179-184, 1988.

Rosenthal NE, Hudson JI, Pope HG, Jr., Wurtman J, Yurgelun-Todd D, Mark S : Bulimia in obese individuals: Relationship to normal-weight bulimia. Journal of Nervous and Mental Disease, 176(3): 144-152, 1988.

Rosenthal NE, Sack DA, James SP, Wehr TA: Deficient nocturnal surge of TSH during sleep and sleep deprivation in rapid-cycling bipolar illness. Psychiatry Research, 23 (2): 179-191, 1988.

Rosenthal NE, Wehr TA, Sack DA: Environmental and behavioral influences on affective illness. Acta Psychiatrica Scandinavica, Supplementum, 77(341): 44-52, 1988.

Rosenthal NE, Kasper S, Wehr TA : Saisonal abhängige Depressionsformen (SAD).I. Grundlagen und klinische Beschreibung des Syndroms. Nervenarzt, 59: 191-199, 1988.

Rosenthal NE, Kasper S, Wehr TA : Saisonal abhängige Depressionsformen (SAD).II. Beeinflussung durch Phototherapie und biologische Ergebnisse. Nervenarzt., 59: 200-214, 1988.

Rosenthal NE, Sack DA, Duncan WC, Mendelson WB, Wehr TA: The timing and duration of sleep in partial sleep deprivation therapy of depression. Acta Psychiatrica Scandinavica. 77(2): 219-224, 1988.

Rosenthal NE, Skwerer RG, Jacobsen FM, Duncan CC, Kelly KA, Sack DA, Tamarkin L, Gaist PA, Kasper S : Neurobiology of seasonal affective disorders and phototherapy. In: Seasonal Affective Disorders and Phototherapy, Journal of Biological Rhythms, 3: 135-154, 1988.

Rosenthal NE, Kasper S, Wehr TA: Hormonal rhythms in affective disorders and their reaction to sleep deprivation and light therapy. Neuroendocrinology Letters, 0(4): 209, 1988.

Rosenthal NE, Kasper S, Wehr TA, Rogers SLB : Seasonality and the effects of light therapy in the general population. Psychopharmacology, 96 (Suppl): 114, 1988.

Rosenthal NE, Skwerer RG, Jacobsen FM, Duncan CC, Kasper S, Schulz PM, Tamarkin L, Gaist P, Hardin T, Wehr TA: Neurobiology of seasonal affective disorder and phototherapy. Psychopharmacology, 96 (Suppl): 115, 1988.

Rosenthal NE, Sack DA, Skwerer RG, Jacobsen FM, Wehr TA: Phototherapy for seasonal affective disorder. Journal of Biological Rhythms, 3(2): 101-120, 1988.

Rosenthal NE, Kasper S, Rogers SL, Yancey AL, Schulz PM, Skwerer RG : Phototherapy in subsyndromal seasonal affective disorder (S-SAD) and "diagnosed" controls. Pharmacopsychiatry, 21(6): 428-429, 1988

Rosenthal NE, Schulz PM, Goldberg S, Wehr TA, Sack DA, Kasper S : Personality as a dimension of summer and winter depression. Psychopharmacology Bulletin, 24(3): 476-483, 1988.

Rosenthal NE, Genhart MJ, Caballero B, Jacobsen FM, Skwerer RG, Coursey RD, Rogers S, Spring BJ.: Psychobiological effects of carbohydrate- and protein-rich meals in patients with seasonal affective disorder and normal controls. Biological Psychiatry, 25: 1029-1040, 1989.

Rosenthal NE, Wehr TA .: Seasonality and Affective Illness. American Journal of Psychiatry, 146(7): 829-839, 1989.

Rosenthal NE, Kasper S, Wehr TA, Bartko JJ, Gaist PA : Epidemiological findings of seasonal changes in mood and behavior. A telephone survey of Montgomery County Maryland. Archives of General Psychiatry, 46(9): 823-833, 1989.

Rosenthal NE, Kasper S, Rogers SLB, Yancey A, Schulz PM, Skwerer RG : Phototherapy in individuals with and without subsyndromal seasonal affective disorder. Archives of General Psychiatry, 46(9): 837-844, 1989.

Rosenthal NE, DellaBella P, Hahn L, Skwerer RG: Seasonal affective disorder and visual impairment: Two case studies. Journal of Clinical Psychiatry, 50(12): 469-472, 1989.

Rosenthal NE, Levendosky AA, Skwerer RG, Joseph-Vanderpool JR, Kelly KA, Hardin T, Kasper S, DellaBella, P, Wehr TA: Effects of light treatment on core body temperature in seasonal affective disorder. Biological Psychiatry 27: 39-50, 1990.

Rosenthal NE, Kasper S, Rogers SLB, Madden PA, Joseph-Vanderpool JR : The effects of phototherapy in the general population. Journal of Affective Disorders, 18: 211-219, 1990.

Rosenthal NERosen LN, Targum, SD, Terman M, Bryant, MJ, Hoffman H, Kasper SF, Hamovit JR, Docherty JP, Welch B . Prevalence of seasonal affective disorder at four latitudes. Psychiatry Research, 31: 131-144, 1990.

Rosenthal NE, Doghramji K, Gaddy JR, Stewart KT, Brainard GC.: Two- versus four-hour evening phototherapy of seasonal affective disorder. Journal of Nervous and Mental Disease, 178(4): 257-260, 1990.

Rosenthal NE, Joseph-Vanderpool JR, Levendosky AA, Johnston SH, Allen R, Kelly KA, Souetre E, Schulz PM, Starz BK: Phase-shifting effects of bright morning light treatment in patients with delayed sleep phase syndrome. Sleep, 13(4): 354-361, 1990.

Rosenthal NE, Brainard GC, Sherry D, Skwerer RG, Waxler M, Kelly KA : Effects of different wavelengths in seasonal affective disorder. Journal of Affective Disorders, 20: 209-216, 1990.

Rosenthal NE, Joseph-Vanderpool JR, Chrousos G, Wehr TA, Kasper S, Gold PW: Abnormal pituitary-adrenal responses to CRH in patients with seasonal affective disorder: Clinical and pathophysiological implications. Journal of Clinical Endocrinology and Metabolism, 72(6): 1382-1387, 1991.

Rosenthal NE, Levendosky AA, Joseph-Vanderpool JR, Hardin T, Sorek E, Core body temperature in patients with seasonal affective disorder and normal controls in summer and winter. Biological Psychiatry, 29(6): 524-534, 1991.

Rosenthal NE, Oren D, Brainard GC, Johnston S, Joseph-Vanderpool JR, Sorek E : Phototherapy of seasonal affective disorder with green versus red light. American Journal of Psychiatry, 148(4): 509-511, 1991.

Rosenthal NE, Oren D, Joseph-Vanderpool JR : Adaptation to dim light in depressed patients with seasonal affective disorder. Psychiatry Research, 36: 187-193, 1991.

Rosenthal NE, Albert PS, Rosen LN, Alexander JR : Effects of daily variations in weather and sleep on patients with seasonal affective disorder. Psychiatry Research, 36(2): 51-63, 1991.

Rosenthal NE, Gaist PA, Obarzanek E, Skwerer RG, Duncan CC, Shultz PM : The effects of bright light on resting metabolic rate in patients with seasonal affective disorder and control subjects. Biological Psychiatry, 28: 989-996, 1990.

Rosenthal NE, Hardin TA, Wehr TA, Brewerton T, Kasper S, Berretini W, Rabkin J : Evaluation of seasonality in six clinical populations and two normal populations. Journal of Psychiatric Research, 25: 75-87, 1991.

Rosenthal NE, Kasper S, Barberi S, Williams A, Tamarkin L, Rogers SLB, Pillemer SR: Immunological correlates of seasonal fluctuations in mood and behavior and their relationship to phototherapy. Psychiatry Research, 36: 253-264, 1991.

Rosenthal NE, Oren DA, Shannon NJ, Carpenter CJ : Usage patterns of phototherapy in seasonal affective disorder. Comprehensive Psychiatry, 32(2): 147-152, 1991.

Rosenthal NE, Rosen LN, Livingstone I : Multiple sclerosis and latitude: A new perspecitive on an old association. Journal of Medical Hypotheses, 36(4): 376-378, 1991.

Rosenthal NE, Parry BL, James SP, Wehr TA: Atenolol in premenstrual syndrome: A test of the melatonin hypothesis. Psychiatry Research, 37: 131-138, 1991.

Rosenthal NE,,Yoney TH, Pigott TA, L'Heureux F : Seasonal variation in obsessive compulsive disorder: Preliminary experience with light treament. American Journal of Psychiatry, 148(12): 1727-1729, 1991.

Rosenthal NE, Rosen LN,: Seasonal variations in mood and behavior in the general population: A factor-analytic approach. Psychiatry Research, 38: 271-283, 1991.

Rosenthal NE, Wehr TA, Giesen HA, Schulz PM, Anderson JL, Joseph-Vanderpool JR, Kelly KA, Kasper S : Contrasts between symptoms of summer depression and winter depression. Journal of Affective Disorders, 23f, 173-183, 1991.

Rosenthal NE,,Oren DA, Jacobsen FM, Wehr TA, Cameron CL : Predictors of response to phototherapy in seasonal affective disorder. Comprehensive Psychiatry, 33(2): 111-114, 1992.

Rosenthal NE, Cohen RM, Gross M, Nordahl TE, Semple WE, Oren DA, Rogers S : The metabolic brain pattern of patients with winter seasonal affective disorder. Archives of General Psychiatry, 49(7): 545-552, 1992.

Rosenthal NE, Moul DE, Hellekson CJ, Oren DA, Frank A, Brainard GC, Murray MG, Wehr TA: A multicenter study of the light visor for seasonal affective disorder: No difference in efficacy found between two different intensities. Neuropsychopharmacology, 8(2): 151-160, 1993.

Rosenthal NE, Rudorfer MV, Skwerer RG : Biogenic amines in seasonal affective disorder: Effects of light therapy. Psychiatry Research, 46: 19-28, 1993.

Rosenthal NE, Leibenluft E, Fiero PL, Bartko JJ, Moul DE : Depressive symptoms and the self-reported use of alcohol, caffeine, and carbohydrates in normal volunteers and four groups of psychiatric outpatients. Amer. Journal of Psychiatry, 150(2): 294-301, 1993.

Rosenthal NE, Genhart MJ, Kelly KA, Coursey RD, Datiles M : The effects of bright light on the mood of normal elderly women. Psychiatry Research, 47: 87-97, 1993.

Rosenthal NE, Oren DA, Moul DE, Schwartz PJ, Alexander JR, Yamada E : An investigation of ophthalmic function in winter seasonal affective disorder. Depression, 1: 29-37, 1993.

Rosenthal NE, Barbato G, Moul DE, Schwartz P, Oren DA: Spontaneous eye blink rate in winter seasonal affective disorder. Psychiatry Research, 47(1): 79-85, 1993.

Rosenthal NE, Joseph-Vanderpool JR, Jacobsen FM, Murphy DL, Hill JL : Seasonal variation in behavioral responses to m-CPP in patients with seasonal affective disorder and controls. Biological Psychiatry, 33: 496-504, 1993.

Rosenthal NE, Leibenluft E, Madden PA, Dick SE : Primary depressives with secondary alcoholism compared with alcoholics and depressives. Comprehensive Psychiatry, 34(2), 83-86, 1993.

Rosenthal NE, Ozaki N, Moul DE, Schwartz PJ, Oren DA: Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder. Psychiatry Research, 49(2): 99-107, 1993.

Rosenthal NE, Anderson J, Rosen LN, Mendelson WB, Jacobsen FM, Skwerer RG, Joseph-Vanderpool JR, Duncan CC, Wehr TA : Sleep in fall/winter seasonal affective disorder: Effects of light and changing seasons. Journal of Psychosomatic Research, 38(4), 323-337, 1994.

Rosenthal NEOren DA, Moul DE, Schwartz PJ, Brown C, Yamada EM : Exposure to ambient light in patients with winter seasonal affective disorder. American Journal of Psychiatry, 151 (4): 591-594, 1994.

Rosenthal NE, Oren DA, Moul DE, Schwartz PJ, Wehr TA,: A controlled trial of levodopa plus carbidopa in the treatment of winter seasonal affective disorder: A test of the dopamine hypothesis. Journal of Clinical Psychopharmacology, 14(3), 196-200, 1994.

Rosenthal NE, Brown C, Oren DA, Galetto G, Schwartz PJ, Malley JD: Effects of light on T-cells in HIV-infected subjects are not dependent on history of seasonal affective disorder. Photochemistry and Photobiology, 59(3), 314-319, 1994.

Rosenthal NE, Oren DA, Schulkin J : 1,25 (OH)Vitamin Dlevels in seasonal affective disorder: Effects of light. Psychopharmacology, 515-516, 1994.

Rosenthal NE, Jacobsen FM, Mueller EA, Rogers S, Hill JL, Murphy DL. Behavioral responses to intravenous meta-chlorophenylpiperazine in patients with seasonal affective disorder and control subjects before and after phototherapy. Psychiatry Research, 52, 181-197, 1994.

Rosenthal NE, Brewerton TD, Krahn DD, Hardin TA, Wehr TA : Findings from the Seasonal Pattern Assessment Questionnaire in patients with eating disorders and control subjects: effects of diagnosis and location. Psychiatry Research, 52(1), 71-84, 1994.

Rosenthal NE, Oren DA, Teicher MH, Schwartz PJ, Glod C, Turner E, Ito YN, Sedway J, Wehr TA: A controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder. Journal of Affective Disorders, 32: 197-200, 1994.

Rosenthal NE, Garcia-Borreguero D, Jacobsen FM, Murphy DL, Joseph-Vanderpool JR, Chiara A. Hormonal Responses to the administration of m-Chlorophenyl-iperazine in patients with seasonal affective disorder and controls. Biological Psychiatry, 37: 740-749, 1994.

Rosenthal, NE. Multiple Chemical Sensitivity: Lessons from SAD. Toxicology and Industrial Health, 10: 623-632, 1994.

Rosenthal NE, Ozaki N, Pascale M, Chiueh CC, Hardin T, Garcia-Borreguero D, Schwartz PJ, Turner E, Oren DA, Murphy DL: Platelet [H] paroxetine binding, 5-HT - stimulated Ca response, and 5-HT content in winter seasonal affective disorder. Biological Psychiatry, 36 (7): 458-466, 1994.

Rosenthal NELeibenluft E, Hardin T : Gender differences in seasonal affective disorder. Depression, 3: 13-19, 1995.

Rosenthal NE, Leibenluft E, Turner EH, Feldman-Naim S, Schwartz PJ, Wehr TA . Light therapy in patients with rapid cycling bipolar disorder: Preliminary results. Psychopharmacol Bull, 31 (4): 705-710, 1995.

Rosenthal NE, Garcia-Borreguero D, Jacobsen FM, Murphy DL, Joseph-Vanderpool JR, Chiara A. Hormonal responses to the administration of m-chlorophenyl-piperazine in patients with seasonal affective disorder and controls. Biological Psychiatry, 37 (10): 740-749, 1995.

Rosenthal NE, Ozaki N, Ono Y, Ito A . The prevalence of seasonal difficulties among Japanese civil servants. American Journal of Psychiatry, 152: 1225-1227, 1995.

Rosenthal NE, Ozaki N, Myers F, Schwartz PJ, Oren DA. Effects of season on electro-oculographic ratio in winter seasonal affective disorder. Psychiatry Research, 59 (1-2): 151-155, 1995.

Rosenthal NE, Swedo SE, Pleeter JD, Richter DM, Hoffman CL, Allen AJ, Hamburger SD, Turner E, Yamada EM . The rates of seasonal affective disorder in children and adolescents. American Journal of Psychiatry, 152 (7): 1016-1019, 1995.

Rosenthal NE, Teicher MH, Oren DA, Schwartz P, Glod CA, Brown C. The phototherapy light visor: There is more to it than meets the eye. American Journal of Psychiatry, 152: 1197-1202, 1995.

Rosenthal NE, Turner EH, Leibenluft E, Albert PS. Effect of season and light treatment upon hot flashes in a perimenopausal SAD patient. Chronobiology International, 12 (4): 290-297, 1995.

Rosenthal NE, Wehr TA, Schwartz PJ, Turner RM, Feldman-Naim S, Drake C. Bimodal patterns of human melatonin secretion consistent with a two-oscillator model of regulation. Neuroscience Letter, 194(1-2): 105-108, 1995.

Rosenthal NE, Schwartz PJ, Wehr TA, Bartko JJ, Oren DA, Luetke C, Murphy DL. Serotonin and thermoregulation: Physiologic and pharmacologic aspects of control revealed by intravenous m-CPP in normal human subjects. Neuropsychopharmacology; 13 (2): 105-115, 1995.

Rosenthal NE, Oren DA, Schwartz PJ, Turner EH. Olfactory function in winter seasonal affective disorder. American Journal of Psychiatry, 152(10): 1531-2,1995.

Rosenthal NE. Syndrome triad in children and adolescents. American Journal of Psychiatry, 152(9): 1402, 1995.

Rosenthal NE, Madden PAS, Heath AC, Martin NG. Seasonal changes in mood and behavior: The role of genetic factors. Archives of General Psychiatry, 53: 47-55, 1996.

Rosenthal NE, Oren DA, Levendosky AA, Kasper S, Duncan CC. Circadian profiles of cortisol, prolactin and thyrotropin in seasonal affective disorder. Biological Psychiatry, 39:157-170, 1996.

Rosenthal NE, Palinkas LA, Houseal M. Subsyndromal seasonal affective disorder in Antarctica. Journal of Nervous Mental Disease, 184 (9): 530-534, 1996.

Rosenthal NE, Ozaki N, Ullamari P, Lappalainen J, Feldman-Naim S, Schwartz PJ, Turner E, Goldman D. Two naturally occurring amino-acid substitutions of the 5-HT2A receptor: similar prevalence in patients with seasonal affective disorder and controls. Biological Psychiatry, 40: 1267-1272, 1996.

Rosenthal NE, Clark CH, Hedaya R. Seasonal depression in patients with disso-iative disorders. Journal of Nervous and Mental Diseases, 184 (7): 433-7, 1996.

Rosenthal NE, Drake C., Schwartz PJ, Turner EH . Cognitive performance in seasonal affective disorder: Pattern recognition and the stroop task. Journal of Nervous Mental Diseases, 184 (1): 56-59, 1996

Rosenthal NE, Schwartz PJ, Brown C, Wehr TA. Winter-SAD: A follow-up study of the first 59 patients of the NIMH seasonal studies program. American Journal of Psychiatry, 153 (8): 1028-1036, 1996.

Rosenthal NE, Leibenluft E, Albert PS, Wehr TA. Relationship between sleep and mood in patients with rapid-cycling bipolar disorder. Psychiatry Research, 63(2-3): 161-8, 1996.

Rosenthal NE, Schwartz PJ, Turner EH, Drake CL, Wehr TA. Seasonal variation in core temperature regulation during sleep in patients with winter seasonal affective disorder. . Biological Psychiatry, 42 (2): 122-31, 1997.

Rosenthal NE, Schwartz PJ, Murphy DL, Garcia-Borreguero D, Oren DA, Moul DE, Ozaki N, Snelbaker AJ, Wehr TA. Effects of m-CPP infusions in patients with Seasonal Affective Disorder and healthy controls: Diurnal responses and nocturnal regulatory mechanisms. Archives of General Psychiatry, 54(4): 375-85, 1997.

Rosenthal NE, Swedo SE, Allen AJ, Glod CA, Teicher M, Richter D, Hoffman C, Brown C, Clark CH. A controlled trial of light therapy for the treatment of pediatric seasonal affective disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 36(6): 816-21, 1997.

Rosenthal NE, Ozaki N, Manji H, Lubierman V, Jia Lu S, Lappaleinen J, Goldman D. A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization, Journal of Neurochemistry, 68 (5): 2186-93, 1997.

Rosenthal NE, Schwartz PJ, Loe JA, Bash CN, Bove K, Turner EH, Frank J, Wehr TA : Seasonality and pituitary size: Evidence for a season by gender effect. Psychiatry Research, 74(3): 151-7, 1997.

Rosenthal NE, Clark C, Schocket LS, Turner EH. Light visor maintenance of light box response. American Journal of Psychiatry, 154 (8):1172, 1997.

Rosenthal NE, Feldman-Naim S. A case of seasonal trichotillomania. Journal of Clinical Psychiatry, 58(5): 218-9, 1997.

Rosenthal NE, Leibenluft E, Feldman-Naim S, Turner E, Wehr TA, . Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. Journal of Clinical Psychiatry, 58: 383-388, 1997.

Rosenthal NE, Neumeister A, Turner EH, Matthews JR, Postolache TT, Barnett RL, Rauh M, Vetticad RG, Kasper S. Effects of tryptophan depletion versus catecholamine depletion in patients with seasonal affective disorder remitted on light therapy. Archives of General Psychiatry, 55: 524-530, 1998.

Rosenthal NE, Mazzanti CM, Barnett RL, Turner EH, Lam GK, Goldman D. Role of Serotonin Transporter Promoter Repeat Length Polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. Journal of Molecular Psychiatry, 3: 175-177, 1998.

Rosenthal NE, Schwarz PJ, Wehr TA. Serotonin 1A receptors, melatonin, and the proportional control thermostat in patients with winter depression. Archives of General Psychiatry, 55: 897-903, 1998.

Rosenthal NE, Postolache TT, Hardin TA, Myers FS, Turner EH, Yi LY, Barnett RL, Matthews JR. Greater improvement in summer than with light treatment in winter in patients with seasonal affective disorder. American Journal of Psychiatry, 155 (11): 1614-1616, 1998.

Rosenthal NE, Garcia-Borreguero D, Dale JK, Chiara A, O’Fallon A, Bartko JJ, Straus SE. Lack of seasonal variation of symptoms in patients with chronic fatigue syndrome. Psychiatry Research, 77: 71-77, 1998.

Rosenthal NE, Giedd JN, Swedo SE, Clark CH, . Pediatric seasonal affective disorder: A follow-up report. Journal of American Academy of Child Adolescent Psychiatry, 37:2, 1998,

Rosenthal NE, Enoch MA, Goldman D, Barnett R, Sher L, Mazzanti CM,. Association between seasonal affective disorder and the 5-HT2A promoter polymorphism. Molecular Psychiatry, 4(1): 89-92, 1999.

Rosenthal NE, Han L, Nielsen DA, Jefferson K, Kaye W, Murphy D, Altemus M, Humphries J, Cassano G, Rotondo A, Virkkunen M, Linnoila M, Goldman D. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biological Psychiatry, 45(5): 615-619, 1999.

Rosenthal NE, Schwartz PJ, Turner EH, Garcia Borreguero D, Sedway J, Murphy DL. Serontin hypothesis of winter-depression: Behavioral and neuroendocrine effects of the 5HT (1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and controls. Psychiatry Research, 86(1): 9-28, 1999.

Rosenthal NE, Sher L, Goldman D. The role of genetic factors in seasonal affective disorder and seasonality. Journal of Affective Disorders, 53(3): 203-210, 1999.

Rosenthal NE, Neuhaus IM, Schwartz PJ, Turner EH, Feldman-Naim S, Matthews JR, Lam G . Gender differences in glycosylated hemoglobin levels in seasonal affective disorder patients and controls. Comprehensive. Psychiatry, 40(3): 234-237, 1999.

Rosenthal NE, Williams JB, Terman M, Link MJ, Amira L, . Hypomania interview guide (including hyperthymia): Retrospective assessment version (HIGH-R). Depression Anxiety, 9(2): 92-100, 1999.

Rosenthal NE, Sher L, Wehr TA. Free thryroxine and thyroid-stimulating hormone levels in patients with seasonal effective disorder and matched controls. Journal of Affective Disorders, 56 (2-3): 195-9, 1999.

Rosenthal NE, Han L, Wang K, Cheng Y, Du Z, Primeau F. Summer and winter patterns of seasonality in Chinese college students: A replication. Comprehensive Psychiatry, 41(1): 57-62, 2000.

Rosenthal, NE, Postolache TT, Doty RL, Wehr TA, Jimma LA, Han L,Turner EH, Matthews JR, Neumesiter A, No C, Koger H, Bruder GE, Monorhinal odor identification and depression scores in patients with seasonal affective disorder. Journal of Affective Disorders, 56(1): 27-35, 1999.

Rosenthal NE, Han L, Wang K, Du Z, Cheng Y, Simons JS. Seasonal variations in mood and behavior among Chinese medical students. American Journal of Psychiatry, 157(1): 133-5, 2000.

Rosenthal NE, Sher L, Hardin TA, Greenberg BD, Murphy DL, Li Q, . Seasonality associated with the serotonin transporter promoter repeat length polymorphism. American Journal of Psychiatry, 156(11): 1837, 1999.

Rosenthal NE, Nawab SS, Miller CS, Dale JK, Greenberg BD, Friedman TC, Chrousos GP, Straus SE. Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls. Psychiatry Research, 95 (1): 67-74, July 24, 2000.

Rosenthal NE, Schwartz PJ, Kajimura N, Han L, Turner EH, Bender C, Wehr TA. Ultradian oscillations in cranial thermoregulation and electroencephalographic slow-wave activity during sleep are abnormal in humans with annual winter depression. Brain Res, 866 (1-2): 152-67, June 2, 2000.

Rosenthal NE, Gordon T, Keel J, Hardin TA, Seasonal mood change and neuroticism : the same construct ? Comprehensive Psychiatry, 40 (6): 415-17, Nov-Dec 1999.

Rosenthal NE, Sher L, Goldman D, Ozaki N. The role of genetic factors in the etiology of seasonal affective disorder and seasonality. Journal of Affective Disorders, 53 (3): 203-210, June 1999.

Rosenthal NE, Schwartz PJ, Turner EH, Garcia-Borreguero D, Sedway J, Vetticad RG, Wehr TA, Murphy DL . Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects. Psychiatry Research, 86 (1): 9-28, April 19, 1999.

Rosenthal NE, Avissar S, Schreiber G, Nechamkin Y, Neuhaus I, Lam GK, Schwartz P, Turner E, Matthews J, Naim S. The effects of seasons and light therapy on G protein levels in mononuclear leukocytes of patients with seasonal affective disorder. Archives of General Psychiatry, 56 (2): 178-83, February 1999.

Rosenthal NE, Sher L, Greenberg BD, Murphy DL, Sirota LA, Hamer DH. Pleiotropy of the serotonin transporter gene for seasonality and neuroticism. Psychiatric Genetics, 10(3): 125-30, September 2000.

Rosenthal NE, Sher L, Matthews JR, Turner EH, Postolache TT, Katz KS, Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder. Journal of Psychiatry and Neuroscience, 26(4): 336-8, September 2001.

Rosenthal NE, Schwartz PJ, Wehr TA. Band-specific electroencephalogram and brain cooling abnormalities during NREM sleep in patients with winter depression. Biological Psychiatry, 15;50(8): 627-32, October 2001.

Rosenthal NE, Wehr TA, Duncan WC, Sher L, Aeschbach D, Schwartz PJ, Turner EH, Postolache TT, A Circadian Signal of Change of Seasons in Patients with Seasonal Affective Disorder. Archives of General Psychiatry, 58(12): 1108-1114, December 2001.
Turner EH, Schwartz PJ, Lowe CH, Nawab SS, Feldman-Naim S, Drake CL. Double-blind placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. J Clin Psychopharmacol. 22 (2): 216-220, Apr 22, 2002.

 

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